Transcriptomic profiling of porcine pluripotency identifies species-specific reprogramming requirements for culturing iPSCs
نویسندگان
چکیده
منابع مشابه
Epigenetic Modifiers Facilitate Induction and Pluripotency of Porcine iPSCs
Inadequate silencing of exogenous genes represents a major obstacle to complete epigenetic reprogramming of porcine-induced pluripotent stem cells (piPSCs) by conventional pluripotency transcription factors (OSKM). We tested the hypothesis that epigenetic modification by active DNA or histone demethylation or by inhibition of histone deacetylase would enhance reprogramming and exogenous gene si...
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Embryonic stem cells are promising donor cell sources for cell transplantation therapy, which may in the future be used to treat various diseases and injuries. However, as is the case for organ transplantation, immune rejection after transplantation is a potential problem with this type of therapy. Moreover, the use of human embryos presents serious ethical difficulties. These issues may be ove...
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ژورنال
عنوان ژورنال: Stem Cell Research
سال: 2019
ISSN: 1873-5061
DOI: 10.1016/j.scr.2019.101645